Tollys accelerates development of TLR3 agonist candidates for intravenous administration in immuno-oncology

Tollys accelerates development of TLR3 agonist candidates for intravenous administration in immuno-oncology
Study results will be presented at EuroPCR conference in Paris, France, May 2022
B2 cohort (high dose added to anti-PD-1) of the PDC-LUNG-101 trial with PDC*lung01 therapeutic cancer vaccine candidate for non-small cell lung cancer has been opened and first patients were dosed
Low Intensity Pulsed Ultrasound device can enhance delivery of CAR-T therapies and penetration of checkpoint inhibitors into the brain of preclinical glioma models; increasing probability of long-lasting immunity
• Within treated patient group, trends showed improved cognitive and executive functions, improved language comprehension and verbal memory, in comparison to placebo group
• REGEnLIFE’s technology shown to be safe and well-tolerated by patients
• Initial results open up new possibilities for development of brain-gut stimulation device for prevention and treatment of neurodegenerative diseases
• Investigational AELIX HTI vaccine leads to prolonged period without antiretroviral treatment (ART)
• Vaccine-induced immune T cell responses significantly correlate with prolonged time off ART
• Results support development of combination strategies based on HTI vaccine to control HIV – without the need for ongoing antiretroviral medication
• No currently marketed drugs are able to stop the progression of epilepsy, those available only help manage seizures
• More than 30% of patients do not respond adequately to those drugs carrying risks of structural damage to the brain and nervous system, comorbidities and increased mortality
• Accure Tx’s candidate ACT-03 demonstrates in animal models anti-epileptogenic activity while protecting against cognitive decline